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KMID : 0811720050090000065
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Korean Journal of Physiology & Pharmacology
2005 Volume.9 No. 0 p.65 ~ p.0
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Effects of CGS-12066A on Medial Vestibular Nuclear Neurons
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Jeong Han-Seong
Jang Myung-Joo
Jang Su-Jeong
Park Jin
Park Jong-Seong
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Abstract
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This study aims to explore the effects of a selective 5-HT1B receptor agonist, CGS-12066A, on the neuronal excitability of the rat medial vestibular nuclear neurons. The spontaneous firing rate was decreased, and the membrane potential was hyperpolarized by CGS-12066A. The whole potassium currents were inhibited by CGS-12066A. After the calcium-dependent potassium, currents were blocked, however, CGS-12066A did not inhibit the potassium currents, suggesting that the 5-HT action site is calcium-dependent potassium currents.
Source: Korean Journal of Physiology & Pharmacology.2005 Oct;9(Suppl I):S88-S88
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KEYWORD
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5-hydroxytryptamine, Medial vestibular nucleus, Action potential, Potassium current
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